药物涂层球囊拘禁技术处理冠脉分叉病变的远期疗效观察

Observation on the long-term effect of drug coated balloon in the treatment of coronary bifurcation lesions by using jailed balloon technique

目的评价药物涂层球囊拘禁技术处理冠状动脉分叉病变的远期疗效。方法将自2016年6月至2019年6月在本院确诊的60例冠状动脉分叉病变患者分为两组:药物涂层球囊(drug coated balloon,DCB)组(29例)和普通球囊(conventional balloon,CB)组(31例)。DCB组使用拘禁球囊技术(jailed balloon technique,JBT)利用DCB处理边支,CB组采用CB在JBT条件下处理边支。对比两组患者手术的远期疗效。结果两组患者一般基线资料比较差异均无统计学意义(均P>0.05)。术后9个月,DCB组边支的血管最小管径(minimal lumen diameter,MLD)大于CB组[(1.987±0.206)cm 比(1.840±0.186)cm],两组比较差异有统计学意义(P=0.005);DCB组边支的晚期管腔丢失(late lumenloss,LLL)小于CB组[(0.003 4±0.074 4)cm 比(0.061 9±0.063 9)cm],两组比较差异有统计学意义(P=0.002);DCB 组左室射血分数(left ventricular ejection fractions,LVEF)恢复情况好于CB 组[(56.070±4.527)%比(52.610±3.649)%],两组比较差异有统计学意义(P=0.002)。结论DCB拘禁技术处理冠状动脉分叉病变能更好地保护边支血管,提高患者心脏收缩功能,远期疗效更好。

Objective To evaluate the long-term effect of drug coated balloon in the treatment of coronary bifurcation lesions by using jailed balloon technique.Methods From June 2016 to June 2019,60 patients with coronary artery bifurcation lesions were diagnosed in our hospital.They were divided into two groups:drug coated balloon(DCB)group(29 cases)and conventional balloon(CB)group(31 cases).The DCB group was treated with DCB by using jailed balloon technique(JBT),and the CB group was treated with CB by using JBT.The long-term effects of the two groups were compared.Results There was no statistically significant difference in baseline data between the two groups(all P>0.05).Nine months after the operation,the minimal lumen diameter(MLD)of side branches in the DCB group was greater than that in the CB group[(1.987±0.206)cm vs.(1.840±0.186)cm](P=0.005).The late lumen loss(LLL)of side branches in the DCB group was smaller than that in the CB group[(0.0034±0.0744)cm vs.(0.0619±0.0639)cm](P=0.002).The recovery of left ventricular ejection fraction(LVEF)in the DCB group was better than that in the CB group[(56.070±4.527)%vs.(52.610±3.649)%](P=0.002).Conclusion DCB in the treatment of coronary artery bifurcation lesions by using JBT,can better protect the side branches,improve the cardiac systolic function,with better long-term effect.