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不孕症女性IVF助孕前后凝血四项及D二聚体变化与妊娠结局 被引量:7

Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy
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摘要 目的探讨不孕女性IVF助孕前后凝血四项及D二聚体(D-D)变化与妊娠结局的临床意义。方法收集2016年6月至11月在昆明医科大学第二附属医院生殖医学科行体外受精-胚胎移植助孕的115例患者,检测患者IVF助孕前后凝血四项及DD指标,根据患者是否妊娠分为妊娠组(69例)和非妊娠组(46例),比较两组患者在IVF助孕前/后PT、APTT、FIB、TT及DD的变化有无差异。结果妊娠组IVF助孕后的FIB及DD均值明显高于IVF助孕前[(3.502±0.773)、(1.718±1.107)] vs [(2.875±0.625)、(0.706±3.101)],而TT明显低于IVF助孕前(3.502±0.773)vs(2.875±0.635),差异有统计学意义(P <0.05);非妊娠组IVF助孕后的DD明显高于IVF助孕前(2.058±1.507) vs(0.294±0.244),而TT明显低于IVF助孕前(16.094±0.862) vs(16.830±1.697),差异有统计学意义(P <0.05)。妊娠组与非妊娠组IVF助孕前/后的凝血四项及DD的指标相比,差异无统计学意义(P> 0.05)。结论针对不孕女性IVF-ET助孕前后PT、APTT、FIB、TT及DD等凝血指标的检测有利于及时发现患者凝血功能的异常,提高不孕女性IVF-ET妊娠成功率。 Objective To explore the clinical significance of changes of coagulation tetrad and D-dimer(DD)and pregnancy outcome in infertile women before and after IVF assisted pregnancy.Methods 115 cases of in vitro fertilization and embryo transfer were collected from June to November 2016 in the Department of Reproductive Medicine,the Second Affiliated Hospital of Kunming Medical University.Four coagulation and DD indexes were detected before and after IVF assisted pregnancy.According to whether the patients were pregnant,they were divided into the pregnancy group(69 cases)and non-pregnancy group(46 cases).The changes of PT,APTT,FIB,TT and DD before and after IVF assisted pregnancy were compared between the two groups to see if there were any differences.Results The mean values of FIB and DD after IVF assisted pregnancy in pregnancy group were significantly higher than those before IVF assisted pregnancy(3.502±0.773、1.718±1.107 vs 2.875±0.625、0.706±3.101),while TT was significantly lower than that before IVF assisted pregnancy(3.502±0.773 vs2.875±0.635),with significant difference(P<0.05);DD after IVF assisted pregnancy in non-pregnancy group was significantly higher than that before IVF assisted pregnancy(2.058±1.507 vs 0.294±0.244),while TTF was significantly lower.The difference was significant before IVF assisted pregnancy(16.094±0.862 vs 16.830±1.697)(P<0.05).There was no significant difference in coagulation and DD between the pregnant group and non-pregnant group before and after IVF(P>0.05).Conclusion Detection of PT,APTT,FIB,TT and DD before and after IVF-ET assisted pregnancy in infertile women is helpful to detect abnormal coagulation function in time and improve the success rate of IVF-ET pregnancy in infertile women.
作者 宋家美 陈静思 邓玉梅 侯志金 孟昱时 SONG Jia-mei;CHEN Jing-si;DENG Yu-mei;HOU Zhi-jin;MENG Yu-shi(Dept.of Gynaecology,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)
出处 《昆明医科大学学报》 CAS 2021年第1期85-88,共4页 Journal of Kunming Medical University
基金 昆明医科大学“十三五”校级学科建设重点基金资助项目(J1301819)。
关键词 不孕症 IVF 凝血四项 DD 妊娠结局 Infertility IVF Coagulation DD Pregnancy outcome
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