IL-18水平与慢性荨麻疹关系的Meta分析

A Meta-Analysis of the Relationship Between IL-18 and Chronic Urticaria

目的对IL-18(白细胞介素-18,Interleukin-18)与慢性荨麻疹的关系进行系统评价。方法计算机检索中国知网(CNKI)、万方数据库、维普中国数据库、中国生物医学文献数据库(Sinomed)、Web of Science及PubMed等中英文文献数据库,收集细胞因子IL-18与慢性荨麻疹相关的研究。进行检索的时间范围截止到2019年12月31日。由两名作者完成以下工作,包括相关文献的筛选、各组资料的提取以及纳入文献的偏倚风险评价。后采用Review Manager 5.3软件进行Meta分析。结果本研究共纳入5个原始研究进行Meta分析。慢性荨麻疹患者(病例组)256例,对照组159例。Meta分析结果显示,在慢性荨麻疹患者的血清中,细胞因子IL-18的浓度显著增加,具有统计学意义(P<0.05)。结论细胞因子IL-18与慢性荨麻疹的关系密切,IL-18对慢性荨麻疹的诊疗具有一定临床指导价值。

Objective To evaluate the relationship between cytokines Interleukin-18(IL-18)and chronic urticaria systematically.Methods CNKI,Wanfang Database,CQVIP,Sinomed Database,Web of Science,PubMed were searched by 31 December 2019,to collect studies on IL-18 and chronic urticaria.Two authors screened literature,extracted data,and assessed risk bias.Meta-analysis was conducted by Review Manager 5.3.Results 5 original studies were included in this Meta-analysis.256 patients with chronic urticaria and 159 in control group were included.The results of meta-analysis showed that IL-18 level was significantly higher in the chronic urticaria patients and the differences had statistical significance.Conclusion IL-18 is closely related to chronic urticaria,and IL-18 has clinical guidance value for chronic urticaria.