血流储备分数联合血清ESM-1水平对急性心肌梗死患者PCI术后心血管事件和支架内再狭窄的预测价值

Predictive Value of Fractional Flow Reserve Combined with Serum ESM-1 Level for Cardiovascular Events and In-Stent Restenosisin Patients with AMI After PCI

目的:探究血流储备分数(FFR)联合内皮细胞特异性分子1(ESM-1)对急性心肌梗死(AMI)患者经皮冠状动脉内介入治疗(PCI)后心血管事件(CE)和支架内再狭窄(ISR)的预测价值。方法:回顾性分析182例AMI患者PCI术后CE和ISR的影响因素,及FFR联合ESM-1对PCI术后CE和ISR的预测价值。结果:CE组和ISR组ESM-1分别高于无心血管事件(NCE)组、无支架内再狭窄(NISR)组,FFR值分别低于NCE组、NISR组(P<0.05);FFR联合ESM-1预测CE、ISR的AUC分别为0.874、0.884,均高于单一指标预测能力(P<0.05);ESM-1是AMI患者PCI术后1年内CE的独立风险因素,FFR是术后1年内ISR独立保护因素(P<0.05)。结论:ESM-1是AMI患者PCI术后1年内CE、ISR的独立风险因素,FFR是独立保护因素,两者联合对患者PCI术后CE和ISR的预测价值较高。

Objective:To explore predictive value of fractional flow reserve(FFR)combined with serum endothelial cell specific molecule 1(ESM-1)level for cardiovascular events(CE)and in-stent restenosis(ISR)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:The influencing factors of CE and ISR in the 182 AMI patients after PCI,and the predictive value of FFR combined with ESM-1 for CE and ISR were retrospectively analyzed.Results:ESM-1 in CE group and ISR group was higher than that in non-cardiovascular event(NCE)group and non-ISR(NISR)group,while FFR was lower than that in NCE group and NISR group,respectively(P<0.05).AUC values of FFR combined with ESM-1 for predicting CE and ISR were 0.874 and 0.884,which were higher than those of single index(P<0.05).ESM-1 was an independent risk factor of CE,and FFR was an independent protective factor of ISR within 1 year after PCI in AMI patients(P<0.05).Conclusion:ESM-1 was an independent risk factor of CE and ISR within 1 year after PCI in AMI patients,while FFR was an independent protective factor.The predictive value of their combination detection for CE and ISR is relatively higher.