曲美他嗪联合派拉西林钠舒巴坦钠在老年肺心病患者中的应用效果及对心功能的影响

Effect of trimetazidine combined with paracecillin and sulbactam in elderly patients with pulmonary heart disease and the effect on heart function

目的探讨曲美他嗪联合派拉西林钠舒巴坦钠在老年肺心病患者中的应用效果及对心功能的影响。方法选取2018年5月~2019年5月首都医科大学附属北京天坛医院和北京医院收治的老年肺心病患者78例为研究对象,随机分为对照组和观察组,每组各39例。两组均给予常规方法治疗、干预,对照组采用曲美他嗪治疗,观察组在对照组基础上联合派拉西林钠舒巴坦钠治疗,治疗后对患者效果进行评估,比较两组sST2、NT-proBNP、心肺功能水平及QOL评分。结果两组患者经过治疗后,血清sST2以及NT-proBNP水平均较治疗前明显降低(P<0.05),且观察组下降幅度显著高于对照组(P<0.05);治疗后,两组患者肺功能FEV1/FVC以及MMEF较治疗前有明显改善(P<0.05),观察组肺功能改善水平显著优于对照组(P<0.05);观察组QOL评分明显低于对照组(P<0.05)。结论曲美他嗪联合派拉西林钠舒巴坦钠用于老年肺心病患者能改善血清sST2以及NT-proBNP水平,提高患者心功能水平,亦可提高患者生活质量,可在临床推广应用。

Objective To investigate the effect of trimetazidine combined with paracillin sodium and sulbactam sodium in elderly patients with pulmonary heart disease and its effect on cardiac function.Methods From May 2018 to May 2019,78 elderly patients with pulmonary heart disease in Beijing Tiantan Hospital and Beijing Hospital affiliated to Capital Medical University were selected as subjects and randomly divided into control group and observation group.Both groups were given conventional methods of treatment and intervention.The control group was treated with trimetazidine.The observation group was treated with paracecillin sodium and sulbactam sodium on the basis of the control group.After 6 months of treatment,the effect of the patients was evaluated.Group sST2,NT-proBNP,cardiopulmonary function level and QOL score.Results The levels of serum sST2 and NT-proBNP in the two groups after treatment were significantly lower than that before treatment(P<0.05).T he decline in the observation group was significantly higher than that in the control group(P<0.05).The lung function FEV1/FVC and MMEF were significantly improved compared with before treatment(P<0.05).The improvement level of lung function in the observation group was significantly better than that in the control group(P<0.05).The QOL score in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Trimetazidine combined with paracecillin and sulbactam sodium can improve serum sST2 and NT-proBNP levels in elderly patients with pulmonary heart disease,improve the level of cardiac function,and improve the quality of life of patients.It is worth popularizing and applying.