果糖1,6-二磷酸酯酶研究进展

Research Progress of Fructose-1,6-bisphosphatase

果糖1,6-二磷酸酯酶(FBPase)是糖异生途径中的关键酶,广泛分布于植物、动物及微生物中,研究其功能调控的分子机制具有重要的生物学意义。酵母细胞中只有一种FBPase,它会通过液泡途径或蛋白酶体途径等不同方式降解;高等植物及动物中则有不同亚型的FBPase,分别在植物光合作用及蔗糖和淀粉的合成以及人类血糖调控等过程中发挥重要作用。综述了不同物种中FBPase的分布、生理功能及调控机理的研究进展,旨在为该酶的深入研究提供理论基础。

Fructose-1,6-bisphosphatase(FBPase)is one of the key enzymes in gluconeogenesis,which is widely distributed in plants,animals and microorganism.Exploring the molecular mechanism of FBPase’s functional regulation has great biological influence.There is only one type of FBPase in yeast and the protein can be degraded via vacuolar or 26S proteasome pathway.There are different subtypes of FBPase in higher plants and animals which play important roles in plant photosynthesis,sucrose and starch synthesis and human blood glucose regulation respectively.In this paper,we reviewed the biological distribution,physiological function and metabolic regulation of FBPase in various organisms,which may provide theoretical basis for further study of FBPase.