转运体介导的甲氨蝶呤药物相互作用研究进展

Advances in Transporter-mediated Drug Interactions with Methotrexate

甲氨蝶呤是一种抗叶酸类抗肿瘤药物,临床常用于治疗某些肿瘤性疾病、风湿性关节炎和银屑病,治疗作用显著,但治疗窗较窄。多种转运体参与甲氨蝶呤在体内的处置过程,当甲氨蝶呤与其他药物合用时,易发生基于转运体的药物相互作用,从而导致药物的不良反应或药物疗效的改变。本文通过查阅及分析文献,总结归纳了转运体介导的甲氨蝶呤与其他药物间的相互作用,为甲氨蝶呤的临床合理用药提供参考。

Methotrexate is an anti-folate antitumor drug, which is often used to treat cancer, rheumatoid arthritis and psoriasis. Methotrexate has a significant therapeutic effect, but its treatment window is narrow. Various transporters are involved in the disposal of methotrexate in vivo. When methotrexate is used in combination with other drugs, drug interactions based on transporters are likely to occur, leading to side effects or changes in efficacy. This article summarized the transport-mediated drug-drug innteractions of methotrexate to provide references information for rational administration of medication in clinic.