甲地孕酮联合复方苦参注射液对子宫内膜癌患者血清肿瘤标志物及免疫功能的影响

Effect of medroxyprogesterone combined with compound sophora flavescens injection on serum tumor markers levels and immune function of patients with endometrial carcinoma

目的:探讨甲地孕酮联合复方苦参注射液对子宫内膜癌患者血清肿瘤标志物及免疫功能的影响。方法:选取2017年3月-2019年3月本院收治的子宫内膜癌患者86例,按随机数字表法分为观察组(43例)和对照组(43例)。患者均采用相同的化疗方案治疗后,对照组给予醋酸甲地孕酮治疗,观察组在对照组治疗基础上联合复方苦参注射液治疗。对两组治疗前后血清肿瘤标志物指标、免疫功能相关指标、生活状态相关指标、KPS评分、治疗效果以及不良反应进行比较。结果:治疗后,两组血清人附睾蛋白4、癌胚抗原、糖类抗原125水平均较治疗前降低,KPS评分及患者体质量和日进食量均较治疗前增高,且观察组变化幅度高于对照组;观察组CD3^+、CD4^+、CD4^+/CD8^+水平均较治疗前增高,CD8^+水平降低,客观缓解率(76.1%)和临床获益率(100.0%)高于对照组(51.2%、88.4%),不良反应发生率(30.2%)低于对照组(65.1%)(均P<0.05)。结论:甲地孕酮与复方苦参注射液联合治疗子宫内膜癌疗效更佳,能明显抑制肿瘤生长,促进免疫功能,改善患者生活状态,用药后不良反应更少,值得临床应用。

Objective:To investigate the effect of medroxyprogesterone combined with compound sophora flavescens injection on serum tumor markers levels and immune function of patients with endometrial carcinoma.Methods:From March 2017 to March 2019,86 patients with endometrial cancer were selected and divided into observation group and control group(43 cases in each group)according to the method of random digital table.All patients were given the same chemotherapy regimen.In addition,the patients in the control group were treated with medroxyprogesterone acetate,and the patients in the observation group were treated with compound sophora flavescens injection on the basis of the treatment in the control group.The levels of the serum tumor markers and the relevant indexes of the immune function,and the value of living state related indexes,the scores of KPS,the treatment effect,and the occurrence rate of the adverse reactions of patients were compared between the two groups.Results:After treatment,the levels of serum human epididymal protein 4(HE4),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)of patients in both groups had decreased significantly,but KPS score,body mass value,and daily food intake of the patients in both groups had increased significantly,and the changed degree of these indexes of patients in the observation group were significant more than those of patients in the control group.The levels of CD3,CD4,and CD4/CD8 of patients in the observation group had increased significantly after treatment,but the CD8 level had decreased significantly.The objective remission rate of patients in the observation group(76.1%)and clinical benefit rate(100.0%)of patients in the observation group were significant higher than those(51.2%and 88.4%)of patients in the control group,and the adverse reaction rate of patients in the observation group(30.2%)was significant lower than that(65.1%)of patients in the control group(all P<0.05).Conclusion:Medroxyprogesterone combined with compound sophora flavescens injection for treating patients with endometrial carcinoma has a good clinical effect,which can obviously inhibit the growth of tumor,enhance the immune function,and improve the living conditions of patients with less side effects,so it is worthy of clinical application.