摘要
环状RNA(circRNA)是一类新型内源性非编码RNA,广泛存在于真核生物体中,因其含量丰富、序列保守、结构稳定等特性,是近年来热门的基因表达调节因子。越来越多的研究表明circRNA在影响内皮完整性、血管平滑肌细胞和免疫炎症细胞的功能,以及在驱动动脉粥样硬化(As)斑块起始和稳定中发挥重要作用,因此其可能作为As新型诊断生物标志物和治疗靶标。因此,文章就circRNA在As中研究现状,综述其在As中的功能以及调节机制。
Circular RNA(circRNA)is a new type of endogenous non-coding RNA,widely present in eukaryotic organisms,due to its rich content,conserved sequence,stable structure and other characteristics,it has been a popular gene expression regulator in recent years.More and more studies have shown that circRNA plays an important role in affecting endothelial integrity disorders,the function of vascular smooth muscle cells and immune inflammatory cells,and driving atherosclerosis(As)plaque initiation and stability.It can be used as a new diagnostic biomarker and therapeutic target for As.Therefore,this paper summarized the function and regulatory mechanism of circRNA in As based on the current research status of circRNA in this disease.
作者
王丹
谭真真
付斯麒
王婧
郭会彩
无
WANG Dan;TAN Zhenzhen;FU Siqi;WANG Jing;GUO Huicai;无(Department of Toxicology,School of Public Health,Hebei Medical University,Shijiazhuang,Hebei 050017,China;Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China;Hebei Province Key Laboratory of Environment and Human Health,Shijiazhuang,Hebei 050017,China)
出处
《中国动脉硬化杂志》
CAS
2021年第1期1-9,共9页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(81473292、21976050)
2020年河北医科大学“大学生创新性实验计划”项目(USIP2020078)
河北省自然科学基金项目(B2018206283)。
