摘要
目的:探讨中性粒细胞与淋巴细胞比值(NLR)与2型糖尿病(T2DM)病人不同程度白蛋白尿的相关性。方法:收集T2DM病人299例,按照白蛋白尿程度分为白蛋白尿正常组(NAU组)97例,微量白蛋白尿组(MAU组)91例及临床蛋白尿组(CAU组)111例。分析各组临床资料、NLR及实验室指标特征。结果:MAU组病人年龄、病程、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、超酶C-反应蛋白(hs-CRP)、胱抑素C(Cys-C)及NLR均高于NAU组(P<0.05~P<0.01),高密度脂蛋白胆固醇(HDL-C)低于NAU组(P<0.05);CAU组病人年龄、病程、收缩压、FBG、HbA1c、TC、TG、LDL-C、血肌酐(Cr)、尿酸(UA)、hs-CRP、Cys-C及NLR均高于NAU组(P<0.05~P<0.01),病程、FBG、HbA1c、Cr、UA、hs-CRP及NLR也均高于MAU组(P<0.01),HDL-C低于NAU组(P<0.01)。多元logisitic回归分析显示,病程、收缩压、舒张压、FBG、TG、LDL-C、Cr、hs-CRP、Cys-C及NLR是影响T2DM白蛋白尿的相关因素(P<0.05~P<0.01)。NLR与年龄、病程、FBG、HbA1C、TC、HDL-C、Cr、hs-CRP因素有统计学关联(P<0.05~P<0.01)。结论:NLR与2型糖尿病白蛋白尿的发生相关。
Objective:To investigate the correlation between the neutrophil-to-lymphocyte ratio(NLR)and different levels of albumin in type 2 diabetes mellitus(T2 DM).Methods:Two hundred ninety-nine patients with T2 DM were divided into the NAU group(n=97),MAU group(n=91)and CAU group(n=111)according to the levels of albumin.The clinical data,NLR and biochemical characteristics in three groups were analyzed.Results:The age,course of disease,and levels of FBG,HbA1 c,TC,TG,LDL-C,hs-CRP,Cys-C and NL in MAU group were higher than those in NAU group(P<0.05 to P<0.01),but the level of HDL-C in MAU group was lower than that in NAU group(P<0.05).The age,course of disease,and levels of SBP,FBG,HbA1 c,TC,TG,LDL-C,Cr,UA,hs-CRP,Cys-C and NLR in CAU group were higher than those in NAU group(P<0.05 to P<0.01),the course of disease,FBG,HbA1 c,Cr,UA,hs-CRP and NLR in CAU group were higher than those in MAU group(P<0.05),and the level of HDL-C in MAU group was lower than that in NAU group(P<0.05).The results of multivariate logistic regression showed that the course of disease,and levels of SBP,DBP,FBG,TG,LDL-C,Cr,hs-CRP,Cys-C and NLR were the relevant factors of influencing the albuninuria in T2 DM.The age,duration,and levels of FBG,HbA1 C,TC,HDL-C,Cr and hs-CRP were correlation with NLR(P<0.05 to P<0.01).Conclusions:The NLR is associate with the severity of albuninuria in T2 DM.
作者
申金付
王卓群
李茂
谢树永
康京京
SHEN Jin-fu;WANG Zhuo-qun;LI Mao;XIE Shu-yong;KANG Jing-jing(Department of Endocrinology,Fuyang People's Hospital,Fuyang Anhui 236004,China)
出处
《蚌埠医学院学报》
CAS
2020年第12期1677-1680,共4页
Journal of Bengbu Medical College