非小细胞肺癌骨转移患者外周血常规、肿瘤标志物及钙磷代谢指标变化

Changes of peripheral blood routine,tumor markers and calcium and phosphorus metabolism indexes in non-small cell lung cancer patients with bone metastasis

目的探讨非小细胞肺癌(NSCLC)骨转移患者外周血血常规、肿瘤标志物及钙磷代谢指标变化。方法采用回顾性分析方法,选取我院2015年7月~2020年1月收治的121例NSCLC患者作为研究对象,依据是否发生骨转移分为非转移组与转移组。DxH800血细胞分析仪检测两组患者外周血常规指标,包括红细胞(RBC)、白细胞(WBC)、血小板(PLT)及血红蛋白浓度(Hb);酶联免疫吸附试验(ELISA)检测肿瘤标志物,包括癌胚抗原(CEA)、糖类抗原(CA19-9)、糖类抗原(CA125)、铁蛋白(Ferritin)含量;血钙、血磷浓度检测试剂盒检测钙磷代谢指标,包括血钙、血磷浓度、钙磷乘积。结果转移组患者RBC、PLT、Hb均低于非转移组(P<0.05);转移组患者WBC高于非转移组(P<0.05)。与非转移组相比,CEA、CA125、CA19-9、Ferritin含量均升高(P<0.05)。转移组血钙浓度低于非转移组(P<0.05);血磷浓度、钙磷乘积高于非转移组(P<0.05)。结论NSCLC骨转移患者外周血常规、肿瘤标志物及钙磷代谢指标均发生明显变化。

Objective To investigate the changes of peripheral blood routine,tumor markers and calcium and phosphorus metabolism indexes in patients with non-small cell lung cancer(NSCLC)with bone metastasis.Methods A total of 121 patients with NSCLC treated in our hospital from July 2015 to January 2020 were selected as research objects by retrospective analyses.According to the occurrence of bone metastasis,they were divided into the non-metastasis group and the metastasis group.DxH800 hematology analyzer was used to detect the routine indexes of peripheral blood,including red blood count(RBC),white blood count(WBC),platelet(PLT)and hemoglobin concentration(Hb).Enzyme-linked immunosorbent assay(ELISA)was used to detect tumor markers,including carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125)and Ferritin.Blood calcium and phosphorus concentration detection kit was adopted to detect calcium and phosphorus metabolism indexes,including blood calcium,blood phosphorus concentration and calcium-phosphorus product.Results RBC,PLT and Hb levels in the metastasis group were lower than those in the non-metastasis group(P<0.05).WBC in the metastatic group was higher than that in the non-metastatic group(P<0.05).Compared with non-metastatic group,CEA,CA125,CA19-9,Ferritin contents were increased in the metastasis group(P<0.05).The blood calcium concentration in the metastasis group was lower than that in the non-metastatic group(P<0.05).The blood phosphorus concentration and calcium-phosphorus product in the metastasis group were higher than those in the non-metastatic group(P<0.05).Conclusion Peripheral blood routine,tumor markers and calcium and phosphorus metabolism indexes changed significantly in NSCLC patients with bone metastasis.