血液相容性聚氨酯弹性体的合成与性能研究

Synthesis and Properties of Blood Compatible Polyurethane Elastomer

聚氨酯材料被广泛用于植入导管及药物载体等生物医用领域,但在一些使用环境中,其血液相容性仍然不能达到要求.以聚四氢呋喃醚二元醇(PTMG)、聚碳酸酯二元醇(PC)为软段,异佛尔酮二异氰酸酯(IPDI)为硬段,1,4-丁二醇(BDO)、二甲硫基甲苯二胺(E300)为扩链剂,设计合成了具有良好血液相容性的聚氨酯弹性体.对合成的聚氨酯弹性体进行红外光谱(FT-IR)、差示扫描量热分析(DSC)、力学性能和水接触角的测试,并进行了溶血实验和细胞相容性实验.结果表明,所合成的聚氨酯弹性体具有良好的机械力学性能;溶血和细胞相容性实验显示该材料具有优良的血液相容性.特别是选用IPDI和E-300扩链剂作硬段、PC作软段的聚氨酯弹性体的综合性能最佳,在生物医疗等领域具有一定的应用前景.

Polyurethane materials are widely used in biomedical fields such as implantable catheters and drug delivery.However,their blood compatibility is difficult to meet the rigorous requirements needed for a new generation of biomedical devices.A series of polyurethane elastomers were prepared using polycarbonate diols(PC),polyoxytertramethylene glycol(PTMG),isophorone diisocyanate(IPDI)and chain extender(BDO,E-300)as raw materials.The properties of polyurethane elastomers were investigated by FT-IR spectrum,differential scanning calorimeter(DSC)analysis,mechanical test,water contact angle measurement,hemolysis and cell compatibility test.The mechanical results show that the materials have superior tensile strength and elongation,meanwhile,the homolysis and cells compatibility tests exhibit that they have good biocompatibility.In addition,the materials can achieve the best performance by using IPDI as well as chain extender E-300 as the hard segment and PC as the soft segment.