无溶剂无催化剂条件下三组分一锅合成2,4,6-三芳基嘧啶衍生物的新方法

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triarylpyrimidines under Solvent-Free and Catalyst-Free Conditions

以1,3-二酮、苯甲醛和醋酸铵为原料,成功地开发了一种简便、高效、无溶剂和催化剂的三组分一锅合成法,高收率地得到了2,4,6-三芳基嘧啶化合物.此方法提供了一条"绿色"合成嘧啶骨架新策略.

2,4,6-Triarylpyrimidines were synthesized via a simple,efficient,one-pot,three-component reaction from1,3-dikeones,benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields.This"green"methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.