摘要
胎儿真皮间充质干细胞(FDMSC)是从不携带遗传疾病且未应用流产药物的健康孕妇意外流产胎儿皮肤中提取的一种多功能干细胞,具有外泌体分泌活性,增殖和自我更新能力强,免疫原性低,可向损伤组织归巢,促进组织再生等优点。近年来对FDMSC基本生物学特性、体外诱导分化能力、促进皮肤创面修复等的研究,为未来烧伤患者的临床治疗提供了新方向。本文就FDMSC促进烧伤创面愈合的研究进展进行综述。
Fetal dermal mesenchymal stem cells(FDMSCs)are pluripotent stem cells derived from skin tissue of accidentally aborted fetuses of healthy pregnant women who are free of genetic diseases and do not take abortion drug.FDMSCs have exosome secretion activity,high proliferation and self-renewal abilities,low immunogenicity,and advantages of homing to damaged tissue and promoting tissue regeneration.In recent years,studies on basic biological characteristics,capacity of inducing differentiation in vitro,and promotion of skin wound repair provide new direction for the clinical treatment of burn patients in the future.In this review,we summarize the research advances of FDMSCs in promoting burn wound healing.
作者
潘伊
姜笃银
Pan Yi;Jiang Duyin(Department of Rehabilitation Medicine,the Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250033,China;Department of Emergency,the Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250033,China)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2021年第1期86-89,共4页
Chinese Journal of Burns
基金
国家自然科学基金(81873934)
济南市科技攻关项目(201704129)。
