摘要
采用中红外(MIR)光谱技术(包括一维MIR光谱、二阶导数MIR光谱、四阶导数MIR光谱和去卷积MIR光谱)分别开展盐酸罗哌卡因分子结构的研究。实验发现:盐酸罗哌卡因的主要红外吸收官能团包括:νasCH3-盐酸罗哌卡因、νasCH2-盐酸罗哌卡因、νsCH3-盐酸罗哌卡因、νamide-Ⅰ-盐酸罗哌卡因、νamide-Ⅱ-盐酸罗哌卡因、νamide-Ⅳ-盐酸罗哌卡因、δasCH3-盐酸罗哌卡因、δsCH3-盐酸罗哌卡因、δCH2-盐酸罗哌卡因和ρCH2-盐酸罗哌卡因等。研究发现,采用MIR光谱可以快速鉴别盐酸罗哌卡因分子结构。本项研究为盐酸罗哌卡因结构,建立一个新的方法学,具有应用研究价值。
The molecule structure of ropivacaine hydrochloride was studied by infrared(MIR)spectroscopy(including:one-dimensional MIR spectroscopy,second derivative MIR spectroscopy,fourth derivative MIR spectroscopy and deconvolution MIR spectroscopy).TheνasCH3-Ropivacaine hydrochloride,νasCH2-Ropivacaine hydrochloride,νaCH3-Ropivacaine hydrochloride,νamide-Ⅰ-Ropivacaine hydrochloride,νamide-Ⅱ-Ropivacaine hydrochloride,νamide-Ⅳ-Ropivacaine hydrochloride,δasCH3-Ropivacaine hydrochloride,δsCH3-Ropivacaine hydrochloride,δCH2-Ropivacaine hydrochloride and ρCH2-Ropivacaine hydrochloridewere found also.It was found that the molecule structure of ropivacaine hydrochloride could be distinguished by MIR spectroscopy.A new methodology was established for the study of ropivacaine hydrochloride structure,which has application research value.
作者
白珊珊
贾宗英
赵翠然
马福民
李泽奇
张晓倩
王莉娜
于宏伟
Bai Shanshan;Jia Zongying;Zhao Cuiran;Ma Fumin;Li Zeqi;Zhang Xiaoqian;Wang Lina;Yu Hongwei(Hebei Yipin Pharmaceutical Co.,Ltd.,Shijiazhuang 050000,China;Shijiazhuang University School of Chemical Engineering,Shijiazhuang 050035,China)
出处
《煤炭与化工》
CAS
2020年第12期133-137,146,共6页
Coal and Chemical Industry
基金
2019-2020年度河北省应用技术大学研究会课题(JY2019011)
石家庄学院2020年度专业认证专项教学改革研究与实践项目(ZXJG-202019)。
关键词
盐酸罗哌卡因
红外光谱
结构
ropivacaine hydrochloride
infrared spectrum
structure
