癌症相关成纤维细胞的异质性及其在靶向治疗中的应用

Heterogeneity of cancer-associated fibroblast and its application in targeted therapy

癌症相关成纤维细胞(cancer-associated fibroblasts,CAFs)是肿瘤微环境中最丰富和最关键的组成部分之一,不仅为肿瘤细胞提供物理支持,也在促进或延缓肿瘤发生发展方面起着关键作用。CAFs是一类高度丰富和异质性明显的间充质细胞系,包含大量不同表型和功能的细胞亚群,针对其异质性的靶向治疗也应运而生。本文阐述CAFs来源、表型和功能相关的异质性,以及在靶向治疗中应用的研究进展,以期提高对恶性肿瘤中CAFs的认识。

Cancer-associated fibroblasts(CAFs)are one of the most abundant and critical components in tumor microenvironment,which not only provide physical support for tumor cells,but also play a key role in promoting or delaying tumor occurrence and development.CAFs are a highly abundant and heterogeneous mesenchymal cell line,which contain a large number of cell subsets with different phenotypes and functions.Targeted therapies for CAFs also emerge as demanded.In order to improve the understanding of CAFs in malignant tumors,we elucidate the heterogeneity of CAFs origins,phenotypes and related functions,as well as the research progress of their application in targeted therapy.