冷冻治疗宫颈高级别上皮内病变的临床效果观察

Clinical observation of cryotherapy for high grade intraepithelial lesions of the cervix

目的观察冷冻治疗宫颈高级别上皮内病变的临床效果。方法将本院收治的87例宫颈高级别上皮内病变患者随机分为两组,观察组44例采用冷冻治疗+保妇康栓治疗,对照组43例采用单纯保妇康栓治疗,比较两组的临床效果。结果观察组、对照组总有效率分别为97.73%、72.09%,组间差异有统计学意义(P<0.05);观察组治疗后C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素10(IL-10)、白细胞介素1β(IL-1β)改善较对照组明显,组间差异有统计学意义(P<0.05)。结论冷冻治疗宫颈高级别上皮内病变的临床疗效较高,血清炎性因子水平改善明显,宫颈病变治愈率高,CIN分级下降明显,具有较高的临床推广价值。

Objective:To observe the clinical effect of cryotherapy for high grade intraepithelial lesions of the cervix.Methods:Eighty-seven patients with high-grade cervical intraepithelial lesions admitted to our hospital were randomly divided into two groups.The observation group was treated with cryotherapy+Baofukang suppository,and the control group was treated with simple Baofukang suppository.The clinical effects of the groups were compared.Results:The total effective rate of the observation group and the control group were 97.73%and 72.09%,respectively.The difference between the two groups was statistically significant(P<0.05).The C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)were treated in the observation group.The improvement of interleukin-10(IL-10)and interleukin-1β(IL-1β)was significantly higher than that of the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The clinical efficacy of cryotherapy for high grade intraepithelial lesions of the cervix is high,and the serum inflammatory factor level is improved obviously,which has a high promotion value.