艾地苯醌对放射性脑损伤患者的疗效研究

Study on the Effect of Idebenoneon Patients with Radiation⁃Induced Brain Injury

目的:探讨艾地苯醌对鼻咽癌放疗后认知功能障碍者的认知功能及生存质量的影响.方法:本研究采取回顾性分析,选取中山大学孙逸仙纪念医院2016年8月至2018年8月治疗的放射性脑损伤后出现认知功能障碍的55例患者为对象,其中接受常规药物治疗的患者为对照组,共28例;接受常规药物治疗联合艾地苯醌组为实验组,共27例,并分析常规药物合并艾地苯醌治疗对鼻咽癌放疗后认知功能障碍的疗效.结果:艾地苯醌组治疗后认知功能评分改善程度显著优于对照组(P<0.05)且显著改善社会关系领域及环境领域.结论:艾地苯醌可显著提高鼻咽癌放疗后脑损伤患者的认知功能障碍,且改善患者的生存质量.

Objective:To investigate the effect of idebenone on the cognitive function and quality of life of patients with cognitive impairment after radiotherapy for nasopharyngeal carcinoma.Methods:This study adopted a retrospective analysis and selected 55 patients with cognitive dysfunction after radiation brain injury treated from August 2016 to Au⁃gust 2018 at Sun Yat⁃sen Memorial Hospital of Sun Yat⁃Sen University,among which the patients who received conven⁃tional drug treatment were The control group has 28 cases;the conventional drug treatment combined with idebenone is the experimental group,a total of 27 cases,and the efficacy of conventional drugs combined with idebenone treatment on cognitive dysfunction after radiotherapy for nasopharyngeal carcinoma is analyzed.Results:The improvement of cog⁃nitive function scores in the idebenone group was significantly better than that of the control group(P<0.05)and signifi⁃cantly improved the social relations and environmental fields.Conclusion:Idebenone can significantly improve the cog⁃nitive dysfunction of patients with brain injury after radiotherapy for nasopharyngeal carcinoma,and improve the quality of life of patients.