昼夜节律通过炎症系统对不稳定动脉粥样硬化斑块的影响

Effects of Circadian Rhythms on Unstable Atherosclerosis Plaques Through Inflammatory System

目的研究人循环血中具有昼夜节律性的基因,分析其相关炎症功能,及其对动脉粥样硬化的潜在影响。方法通过分析人循环血液中具有昼夜表达节律性基因的相关数据,利用LSPR算法分析其中基因表达的昼夜节律性,利用GOterm数据库分析相关基因主要功能集中免疫炎症,结合人动脉粥样硬化不稳定斑块高表达相关基因,分析昼夜节律性炎症因子对易损斑块的影响。结果具有昼夜节律性的相关基因主要功能为免疫炎症、淋巴细胞激活、白细胞激活、细胞因子的调节、T细胞激活等,相关炎症基因与不稳定冠状动脉粥样硬化斑块相关,昼夜节律干扰后相关节律性减弱或消失。结论人循环血中具有昼夜节律性的因子的主要功能与免疫炎症相关,部分因子在易损斑块斑块中也高表达,节律紊乱干扰相关炎症因子节律性,其潜在影响急性冠脉事件的发生。

Objective To study genes with circadian rhythms in the human blood,and to analyze their associated inflammatory functions and potential effects on atherosclerosis.Methods By analyzing the data of the genes with circadian rhythm in the blood of human circulation,using the LSPR algorithm to analyze the circadian rhythm of gene expression,using the GOterm database to analyze the main function of the relevant gene concentrated immune inflammation,combined with the human unstable atherosclerotic plaque high-expression genes,analysis the effect of circadian rhythm inflammatory factors on the vulnerable plaques.Results The main functions of the genes associated with circadian rhythms were immune inflammation,lymphocyte activation,white blood cell activation,cell factor regulation,T-cell activation,etc.,the relevant inflammatory genes were associated with unstable coronary atherosclerosis plaques,and the associated rhythms decreased or disappeared after circadian rhythm interference.Conclusion The main function of factors with circadian rhythm in human circulatory blood is related to immune inflammation,some factors are also highly expressed in vulnerable plaques,and rhythmic disorders interfere with the rhythm of related inflammatory factors,which potentially affect the occurrence of acute coronary events.