PLR和AST水平与肝细胞癌消融术后早期复发转移的关系研究

THE RELATIONSHIP BETWEEN PLR AND AST LEVELS AND EARLY RECURRENCE AND METASTASIS OF HEPATOCELLULAR CARCINOMA AFTER ABLATION

目的探讨血小板-淋巴细胞比率(PLR)、天门冬氨酸氨基转移酶(AST)与肝细胞癌消融术后早期复发转移的关系。方法选取2016年1月—2018年2月该院治疗的肝细胞癌患者110例,收集随访资料、PLR、AST等。结果随访2年内,发生复发转移患者68例;发生复发转移患者AST、PLR、AFP和肿瘤≥2个比例分别为(73.54±8.91)U/L、(129.29±32.22)、(13.30±3.22)ng/ml和66.18%,明显高于未发生复发转移患者(均P<0.05);Logistic回归分析结果显示,PLR、AST和肿瘤≥2个是肝细胞癌消融术后早期复发转移的相关因素(OR=2.275、1.923和2.020,P<0.05);PLR、AST和联合检查预测复发转移的ROC曲线下面积分别为0.680、0.732和0.832,差异均有统计学意义(均P<0.05)。结论PLR、AST可能是肝细胞癌消融术后早期复发转移的相关因素,在预测早期复发转移中有一定价值。

Objective To investigate the relationship between platelet-lymphocyte ratio(PLR),aspartate aminotransferase(AST)and early recurrence and metastasis of hepatocellular carcinoma after ablation.Methods one hundred and ten patients with hepatocellular carcinoma treated in The 986 Hospital of air force from January 2017 to February 2019 were selected to collect follow-up data,PLR,AST,et al.Results During the follow-up of 2 years,68 patients had relapse and metastasis.The ratio of AST,PLR,AFP and tumor≥2 in patients with recurrence and metastasis were(73.54±8.91)U/L,(129.29±32.22),(13.30±3.22)ng/ml and 66.18%,which was significantly higher than that of patients without recurrence and metastasis(P<0.05).The results of Logistic regression analysis showed that PLR、AST and tumor≥2 were the factors related toearly recurrence and metastasis of hepatocellular carcinoma after ablation(OR=2.275,1.923 and 2.020,P<0.05).The area under ROC curve predicted recurrence and metastasis by PLR,AST and combined examination were 0.680,0.732 and 0.832,respectively(P<0.05).Conclusion PLR and AST may be related factors of early recurrence and metastasis after hepatocellular carcinoma ablation,which has certain value in predicting early recurrence and metastasis.