早期肺表面活性物质微创给药在早产儿肺透明膜病预防中的应用

Application of Minimally Invasive Administration of Early Pulmonary Surfactant in the Prevention of Hyaline Membrane Disease in Premature Infants

目的探究早期肺表面活性物质微创给药在早产儿肺透明膜病预防中的应用效果。方法回顾性分析广西科技大学第一附属医院2019年4月至2020年4月分娩的68例早产儿各项临床资料,根据治疗方式不同将应用常规机械通气的早产儿设为对照组,常规机械通气基础上实施早期肺表面活性物质微创给药的早产儿设为观察组,每组34例。记录两组肺透明病发生率、7 d内死亡率、治疗前后血气分析指标。结果观察组肺透明膜病发生率、7 d内死亡率均低于对照组(P<0.05)。治疗后24 h,两组动脉血氧分压(PaO2)、氢离子浓度指数(pH)水平升高,二氧化碳分压(PaCO2)水平下降,比较发现观察组升幅、降幅均大于对照组(P<0.05)。结论早期肺表面活性物质微创给药能够改善早产儿血气分析指标,降低早产儿死亡率、肺透明膜病发生率。

Objective To explore the application effect of early pulmonary surfactant minimally invasive administration in the prevention of hyaline membrane disease in premature infants.Methods Retrospectively analyzed the clinical data of 68 preterm infants delivered from April 2019 to April 2020 at The First Affiliated Hospital of Guangxi University of Science and Technology,and preterm infants who applied conventional mechanical ventilation according to the treatment modality were set as the control group,while preterm infants who implemented early lung surfactant minimally invasive administration on the basis of conventional mechanical ventilation were set as the observation group,34 cases in each group.The incidence of pulmonary hyaline disease,mortality within 7 d,and indexes of blood gas analysis before and after treatment were recorded in the two groups.Results The incidence of hyaline membrane disease and mortality within 7 days in the observation group were lower than those in the control group(P<0.05).24 h after treatment,the partial pressure of oxygen(PaO2)and pH of the two groups increased,and the partial pressure of carbon dioxide(PaCO2)decreased,and the increase and decrease of the observation group were greater than those of the control group(P<0.05).Conclusion Early minimally invasive administration of pulmonary surfactant can improve the blood gas analysis indexes of premature infants,reduce the mortality of premature infants and the incidence of hyaline membrane disease.