山莨菪碱和间苯三酚分别与氟比洛芬酯联合治疗肾绞痛的疗效分析

Effect of Anisodamine and Phloroglucinol Combined with Flurbiprofen Axetil in the Treatment of Renal Colic

目的探讨山莨菪碱、间苯三酚分别与氟比洛芬酯联合治疗肾绞痛的临床效果。方法选取南京同仁医院2018年2月至10月收治的60例因输尿管结石致肾绞痛患者作为研究对象,按照随机数字表法分为对照组(30例)与试验组(30例)。对照组采用山莨菪碱+氟比洛芬酯静脉滴注治疗,试验组采用间苯三酚+氟比洛芬酯静脉滴注治疗。比较两组患者治疗总有效率、疼痛数字评分(NRS)、镇痛起效时间、疼痛缓解持续时间及不良反应发生率。结果试验组患者的治疗总有效率为93.33%,显著高于对照组63.33%(P<0.05);试验组患者经治疗后的15 min、0.5 h、1 h、2 h、4 h、6 h和8 h的NRS评分均优于对照组,且患者的镇痛起效时间和疼痛缓解持续时间分别为(13.01±5.19)h和(4.61±1.49)h,也显著优于对照组的(18.01±6.59)h和(2.82±1.62)h;试验组患者的不良反应发生率为10.00%,显著低于对照组的30.00%,组间比较差异有统计学意义(P<0.05)。结论对肾绞痛患者采用间苯三酚+氟比洛芬酯注射治疗,可大大减轻患者的疼痛感,临床治疗总有效率更高,且不良反应发生率更低,值得推广应用。

Objective To explore the effect of anisodamine,phloroglucinol and flurbiprofen axetil in the treatment of renal colic.Methods A total of 60 patients with renal colic caused by ureteral calculi admitted to Nanjing Tongren Hospital from February to October 2018 were selected as the research objects and randomLy divided into control group and experimental group,with 30 patients in each group.The control group was treated with anisodamine and flurbiprofen axetil,and the experimental group was given ghloroglucinol and flurbiprofen axetil by intravenous drip.The effective rate of treatment,NRS score,onset time of analgesia,duration of analgesia relief and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 93.33%,which was significantly higher than that of the control group 63.33%.The NRS scores of patients in the experimental group were better than those in the control group at 15 min,0.5 h,1 h,2 h,4 h,6 h and 8 h after treatment,and the onset time and duration of analgesia relief were(13.01±5.19)h and(4.61±1.49)h in the experimental group,which were significantly better than(18.01±6.59)h and(2.82±1.62)h in the control group.The incidence of adverse reactions in the experimental group was 10.00%,significantly lower than that in the control group 30.00%,with statistically significant differences(P<0.05).Conclusion The injection of phloroglucinol plus flurbiprofen into renal colic patients can greatly reduce the pain of the patients,with higher clinical treatment efficiency and lower incidence of adverse reactions,which is worthy of promotion and applicatio.