阿司匹林联合氯吡格雷治疗脑梗死的疗效及不良反应发生率评价

Evaluation of the Efficacy and Adverse Reaction Rate of Aspirin Combined with Clopidogrel in the Treatment of Cerebral Infarction

目的分析阿司匹林+氯吡格雷治疗脑梗死的疗效及不良反应发生率。方法选取无锡市惠山区第二人民医院2018年1月至2019年12月住院治疗的60例脑梗死患者,以“单盲随机抽样法”分组,参照组(30例)采用阿司匹林治疗,试验组(30例)采用阿司匹林+氯吡格雷治疗,对比两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活活动能力量表(Barthel)指数、改良Rankin量表(mRS)评分、健康调查问卷(SF-36)评分、不良反应发生率。结果临床总有效率试验组93.33%高于参照组63.33%,治疗后试验组NIHSS评分、mRS评分均低于参照组,治疗后试验组Barthel指数、SF-36评分均高于参照组,差异均具有统计学意义(P<0.05)。试验组不良反应发生率13.33%与参照组6.67%比较,差异无统计学意义(P>0.05)。结论阿司匹林+氯吡格雷应用于脑梗死治疗中,在促进神经功能修复、日常生活能力恢复方面具有重要意义,且不良反应较少。

Objective To analyze the efficacy and incidence of adverse reactions of aspirin plus clopidogrel in the treatment of cerebral infarction.Methods Totally 60 patients with cerebral infarction who were hospitalized in The Second People's Hospital of Huishan District from January 2018 to December 2019 were selected and grouped by"single-blind random sampling".The reference group(30 cases)was treated with aspirin,and the experimental group(30 cases)was treated with aspirin plus clopidogrel treatment,compare the clinical efficacy,NIHSS score,Barthel index,mRS score,SF-36 score,and incidence of adverse reactions between the two groups.Results The total clinical effective rate of the experimental group 93.33%is higher than the reference group 63.33%.After treatment,the NIHSS score and mRS score of the experimental group are lower than the reference group,and the Barthel index and SF-36 score of the experimental group are higher than the reference group after treatment,the differences are statistically significant(P<0.05).The incidence of adverse reactions in the experimental group 13.33%compared with the reference group 6.67%,the differences are not statistically significant(P>0.05).Conclusion Aspirin plus clopidogrel is used in the treatment of cerebral infarction,which is of great significance in promoting the restoration of nerve function and the recovery of daily life ability,and has fewer adverse reactions.