糖尿病视网膜病变易感性与相关基因多态性研究进展

Research progress on susceptibility to diabetic retinopathy and related gene polymorphism

糖尿病视网膜病变(DR)是一种多因素介导的疾病,目前公认DR是由慢性高血糖引起的代谢环境异常所致,但其发生受遗传因素的调控,被认为是人类复杂疾病的经典案例,可归因于遗传因素、环境因素及其之间的相互作用结果。遗传学对DR发生发展的研究已取得了一定成果,但具体的致病基因及其发病机制仍尚未明确。本研究针对目前已确定的潜在DR易感基因及其多态性进行综述,为进一步研究DR致病基因及其发病机制提供参考。

Diabetic retinopathy(DR)is a kind of multi-factor mediated diseases,currently accepted DR environment that is caused by chronic high blood glucose metabolic abnormalities caused by,but it is regulated by the genetic factors,is considered to be a classic case of complex diseases,can be attributed to genetic factors,environmental factors and the interaction of the results.Genetic studies on the occurrence and development of DR have achieved some results,but the specific pathogenic genes and their pathogenesis are still not clear.In this study,potential DR susceptibility genes and their polymorphisms have been identified so far,so as to provide reference for further study of DR pathogenic genes and their pathogenesis.