睡眠呼吸障碍患者黄斑区神经节细胞复合体厚度研究

Alterations of macular ganglion cell complex thickness in obstructive appea

目的:比较不同程度睡眠呼吸障碍患者黄斑区神经节细胞复合体(GCC)的厚度变化。方法:采用横断面研究,收集2015-06/2018-06间于我校附属医院诊断为阻塞性睡眠呼吸障碍综合征的患者和健康体检者,将呼吸暂停低通气指数(AHI)≥5的58例患者纳入睡眠呼吸障碍组,根据AHI值将其分为轻、中、重度三个亚组,将AHI<5的50例健康体检者纳入对照组。采用RTVUE 100-2型相干光断层扫描检查仪对黄斑区视网膜进行扫描,测量黄斑区GCC总体平均厚度(GCC-Avg)、上方平均厚度(GCC-Sup)、下方平均厚度(GCC-Inf)、局部丢失容积(FLV)与整体丢失容积(GLV)。分析比较各组间GCC厚度的差异。结果:不同程度睡眠呼吸障碍组各区GCC厚度均较对照组变薄(P<0.05),但FLV和GLV均较对照组增加(P<0.05),不同程度睡眠呼吸障碍组组间FLV比较无差异(P>0.05),不同程度睡眠呼吸障碍组组间GLV比较有差异(P<0.05)。结论:随着睡眠呼吸障碍程度的加重黄斑区GCC厚度变薄。

AIM:To observe the changes of macular ganglion cell complex(GCC)thickness in patients with obstructive sleep apnea(OSA)and discuss the relativity between thickness of GCC and OSA.METHODS:Fifty-eight patients with OSA whose Apnea-Hypopnea Index≥5 and fifty healthy people whose Apnea-Hypopnea Index<5 were enrolled in this study.OSA patients were further divided into mild,moderate,and severe OSA groups according to their Apnea-Hypopnea Inde.RTVUE 100-2 optical coherence tomography was used to measure the GCC thickness.The examination included average thickness of GCC(GCC-Avg),superior(GCC-Sup)and inferior thickness of GCC(GCC-Inf),focal loss of volume(FLV)and general loss of volume(GLV).The difference in GCC thickness was analyzed among four groups.RESULTS:The thickness of GCC of the OSA groups was thinner than that of the normal control group(P<0.05),and FLV in the OSA groups was higher than that in the normal control group(P<0.05),but there was no significant difference in FLV between OSA groups(P>0.05).GLV increased in the OSA groups compared with the control group.CONCLUSION:The macular GCC thickness decreased in OSA patients,and the thickness of GCC decreased with the increase of OSA patients’severity(AHI).