单硝酸异山梨酯联合卡托普利治疗肺源性心脏病急性发作的临床效果

Clinical Effect of Isosorbide Mononitrate Combined with Captopril on Acute Attack of Cor Pulmonale

目的研究对肺源性心脏病急性发作患者给予单硝酸异山梨酯和卡托普利联合治疗的效果。方法于我院患者中随机抽取76例,使用随机数表分为两组,对照组给予单硝酸异山梨酯,观察组联合给予卡托普利治疗,对比两组心肺功能指标以及不良反应情况。结果对照组FEV1%pred(50.37±3.52)%,FEV1/FVC(61.26±5.53)%,MVV(69.37±4.17)L/min,6MWD(359.80±36.74)m。观察组FEV1%pred(57.42±3.40)%,FEV1/FVC(67.92±5.46)%,MVV(78.84±5.08)L/min,6MWD(431.29±40.86)m。对照组头晕头痛1例(2.63%),胃肠不适1例(2.63%),合计2例(5.26%)。观察组头晕头痛1例(2.63%),咳嗽乏力1例(2.63%),胃肠不适1例(2.63%),合计3例(7.89%)。两组对比,差异显著(P<0.05)。结论对急性发作期肺源性心脏病患者给予单硝酸异山梨酯以及卡托普利联合治疗,有助于改善临床疗效。单硝酸异山梨酯、卡托普利作为临床常见药物,有助于降低肺动脉压,缓解心力衰竭症状,控制病情发展,同时可提高患者心肺功能指标,不会增加用药不良反应,改善患者病情,具有较高安全性保障。

Objective To study the effect of combined treatment of isosorbide mononitrate and captopril on patients with acute cor pulmonale.Method Seventy-six patients were randomly selected from our hospital and divided into 2 groups using a random number table.The control group was given isosorbide mononitrate,and the observation group was given captopril treatment.The two groups were compared with cardiopulmonary function indexes and adverse reactions.Results In the control group,FEV1%pred(50.37±3.52)%,FEV1/FVC(61.26±5.53)%,MVV(69.37±4.17)L/min,6MWD(359.80±36.74)m.In the observation group,FEV1%pred(57.42±3.40)%,FEV1/FVC(67.92±5.46)%,MVV(78.84±5.08)L/min,6MWD(431.29±40.86)m.In the control group,there was 1 case of dizziness and headache(2.63%),1 case of gastrointestinal discomfort(2.63%),and 2 cases(5.26%)in total.In the observation group,there was 1 case of dizziness and headache(2.63%),1 case of cough fatigue(2.63%),1 case of gastrointestinal discomfort(2.63%),3 cases(7.89%)in total.The difference between the two groups was significant(P<0.05).Conclusion The combined treatment of isosorbide mononitrate and captopril in patients with acute-onset cor pulmonale can help improve the clinical efficacy.Isosorbide mononitrate and captopril,as common clinical drugs,help reduce pulmonary artery pressure,relieve symptoms of heart failure,and control the development of the disease.At the same time,it can improve the patient’s cardiopulmonary function indicators without increasing adverse drug reactions and improve the patient’s condition.Has a high security guarantee.