阿司匹林联合硫酸氢氯吡格雷口服治疗脑梗死的临床疗效

Clinical Efficacy of Aspirin Combined with Clopidogrel Bisulfate in the Treatment of Cerebral Infarction

目的分析阿司匹林与硫酸氢氯吡格雷联合治疗脑梗死的效果。方法选取84例患者,就诊的时间为2018年6月至2020年6月。根据随机数字表法将所有患者分为对照组(42例)与观察组(42例),其中对照组接受常规治疗+阿司匹林,观察组在对照组基础上加用硫酸氢氯吡格雷口服。对比两组治疗效果。结果治疗后,两组的血浆凝血酶原时间、凝血酶原活动度相比无差异(P>0.05),观察组的活化部分凝血活酶时间较对照组长(P<0.05);观察组的NIHSS评分、治疗总有效率均较对照组高(P<0.05)。结论脑梗死患者中应用阿司匹林与硫酸氢氯吡格雷联合治疗,可促进脑部血液循环、消除炎性因子,缩小梗死面积,提高治疗效果。

Objective To analyze the effect of aspirin combined with clopidogrel hydrogen sulfate on cerebral infarction.Methods A total of 84 patients were selected and the period of consultation was from June 2018 to June 2020.According to the random number table method,all patients were divided into a control group(42 cases)and an observation group(42 cases).The control group received conventional treatment+aspirin,and the observation group was given clopidogrel bisulfate orally on the basis of the control group.Compare the treatment effects of the two groups.Results After treatment,there was no difference in plasma prothrombin time and prothrombin activity between the two groups(P>0.05).The activated partial thromboplastin time of the observation group was longer than that of the control group(P<0.05);the NIHSS score and the total effective rate of treatment in the observation group were higher than those in the control group(P<0.05).Conclusion Aspirin combined with clopidogrel bisulfate can promote blood circulation in brain,eliminate inflammatory factors,reduce infarct size and improve therapeutic effect.