支气管肺泡灌洗治疗老年重症肺炎合并呼吸衰竭的效果及对免疫功能的影响分析

Analysis of the effect of bronchoalveolar lavage in the treatment of elderly patients with severe pneumonia complicated with respiratory failure and its influence on immune function

目的探究支气管肺泡灌洗治疗老年重症肺炎合并呼吸衰竭的临床效果及对免疫功能的影响。方法80例老年重症肺炎合并呼吸衰竭患者,根据入院顺序分为观察组和对照组,各40例。对照组采用常规治疗,观察组采用支气管肺泡灌洗治疗。观察比较两组患者的临床疗效及肺泡巨噬细胞免疫功能指标。结果观察组患者治疗总有效率97.50%高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组巨噬细胞吞噬率、巨噬细胞杀菌率以及TNF-α水平分别为(22.01±1.72)%、(0.81±0.10)%、(11.89±1.21)ng/L,均高于对照组的(18.66±1.67)%、(0.50±0.05)%、(8.23±0.92)ng/L,差异有统计学意义(P<0.05)。结论对于老年重症肺炎合并呼吸衰竭患者,临床给予支气管肺泡灌洗治疗效果显著,可有效改善机体免疫功能,值得推广。

Objective To investigate the clinical effect of bronchoalveolar lavage in the treatment of elderly patients with severe pneumonia complicated with respiratory failure and its influence on immune function.Methods A total of 80 elderly patients with severe pneumonia complicated with respiratory failure were divided into observation group and control group according to admission order,with 40 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with bronchoalveolar lavage.The clinical efficacy and immune function index of alveolar macrophages were observed and compared between the two groups.Results The total effective rate of treatment 97.50%of the observation group was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).The macrophage phagocytosis rate,macrophage sterilization rate and TNF-αof the observation group were(22.01±1.72)%,(0.81±0.10)%and(11.89±1.21)ng/L,which were all higher than(18.66±1.67)%,(0.50±0.05)%and(8.23±0.92)ng/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Bronchoalveolar lavage has remarkable effect for elderly patients with severe pneumonia complicated with respiratory failure,and it can effectively improve the immune function of patients.It is worthy of promotion.