多巴胺联合硝普钠治疗心梗后左心衰的效果分析

Effect analysis of dopamine combined with sodium nitroprusside in the treatment of left heart failure after myocardial infarction

目的分析心肌梗死(心梗)后左心衰联合应用多巴胺+硝普钠治疗的临床效果。方法100例心肌梗死后左心衰患者,采用随机数字表法分为对照组与研究组,各50例。对照组单用硝普钠治疗,研究组采用硝普钠联用多巴胺治疗。比较两组临床疗效、不良反应发生情况及治疗后心功能指标、6 min步行距离。结果研究组总有效率为94.00%,高于对照组的74.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。研究组左室射血分数(59.07±8.61)%高于对照组的(46.53±5.23)%,左室舒张末期内径(52.11±4.14)mm和左室收缩末期内径(24.43±4.44)mm均短于对照组的(59.79±7.51)、(37.71±7.89)mm,6 min步行距离(471.06±10.79)m长于对照组的(379.48±9.13)m,差异有统计学意义(P<0.05)。结论硝普钠联合多巴胺治疗心肌梗死后左心衰有显著疗效和安全性,可以更有效地改善患者心功能,提高患者运动耐量,使患者具有更好的预后。

Objective To analyze the clinical effect of dopamine combined with sodium nitroprusside in the treatment of left heart failure after myocardial infarction.Methods A total of 100 patients with left heart failure after myocardial infarction were divided into control group and research group according to random numerical table,with 50 cases in each group.The control group was treated with sodium nitroprusside,and the research group was treated with dopamine combined with sodium nitroprusside.The clinical efficacy,occurrence of adverse reactions,cardiac function indicators and 6-min walking distance were compared between the two groups.Results The total effective rate of the research group was 94.00%,which was higher than 74.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).The left ventricular ejection fraction(59.07±8.61)%of the research group was higher than(46.53±5.23)%of the control group,left ventricular end diastolic diameter(52.11±4.14)mm and left ventricular end systolic diameter(24.43±4.44)mm were shorter than(59.79±7.51)and(37.71±7.89)mm of the control group,and 6-min walking distance(471.06±10.79)m was longer than(379.48±9.13)m of the control group,and the difference was statistically significant(P<0.05).Conclusion Dopamine combined with sodium nitroprusside has remarkable efficacy and safety in the treatment of left heart failure after myocardial infarction,which can effectively improve the cardiac function and exercise tolerance,and make the patient have a better prognosis.