氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的效果观察

Effect of amlodipine combined with atorvastatin calcium tablets in the treatment of hypertension complicated with coronary heart disease

目的观察高血压合并冠心病患者应用氨氯地平联合阿托伐他汀钙片治疗的临床效果。方法90例高血压合并冠心病患者,根据入院时间先后顺序分为对照组和观察组,每组45例。对照组采用氨氯地平治疗,观察组采用氨氯地平联合阿托伐他汀钙片治疗。比较两组患者的临床疗效及治疗前后血压、Hcy水平变化。结果治疗前,两组舒张压、收缩压及同型半胱氨酸(Hcy)水平比较,差异无统计学意义(P>0.05);治疗后,观察组舒张压(70.17±5.34)mm Hg(1mm Hg=0.133 kPa)、收缩压(120.35±8.50)mm Hg及Hcy(8.74±1.58)μmol/L均低于对照组的(84.04±5.10)mm Hg、(137.47±10.24)mm Hg、(13.58±1.46)μmol/L,差异有统计学意义(P<0.05)。观察组治疗总有效率为91.11%,高于对照组的75.56%,差异有统计学意义(P<0.05)。结论氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的临床效果较为理想,在临床中推行的可行性较大。

Objective To observe the clinical effect of amlodipine combined with atorvastatin calcium tablets in the treatment of hypertension complicated with coronary heart disease.Methods A total of 90 patients with hypertension complicated with coronary heart disease were divided into control group and observation group according to admission order,with 45 cases in each group.The control group was treated with amlodipine,and the observation group was treated with amlodipine combined with atorvastatin calcium tablets.The clinical efficacy,blood pressure and homocysteine(Hcy)changes before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in diastolic blood pressure,systolic blood pressure and Hcy levels between the two groups(P>0.05).After treatment,the diastolic blood pressure(70.17±5.34)mm Hg(1 mm Hg=0.133 kPa),systolic blood pressure(120.35±8.50)mm Hg and Hcy(8.74±1.58)μmol/L of the observation group were lower than(84.04±5.10)mm Hg,(137.47±10.24)mm Hg and(13.58±1.46)μmol/L of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment of the observation group was 91.11%,which was higher than 75.56%of the control group,and the difference was statistically significant(P<0.05).Conclusion Amlodipine combined with atorvastatin calcium tablets has ideal effect in the treatment of hypertension complicated with coronary heart disease,and it is feasible to be implemented in clinical practice.