肿瘤能量代谢异常及其中医治疗研究

Research Advancement of Energy Metabolism Disorder in Cancer Cell and Its Treatment with Traditional Chinese Medicine

能量代谢异常在肿瘤发生发展的过程中发挥了重要作用。现代研究发现,不同于以往被认为是肿瘤细胞代谢途径受损的结果,这种异常代谢的方式是肿瘤细胞自主选择的基因重编程。目前,针对肿瘤能量代谢异常有效靶点的个体化治疗成为了新的研究热点。本文将综述肿瘤细胞能量代谢重编程特点,并探讨中医药或可从能量代谢途径治疗肿瘤的作用机制,从而使中药抗癌更好地指导临床应用。

Energy metabolism disorder plays an important role in the development of cancer.It has been proved recently that energy metabolism mode of cancer cell is the result of gene reprogramming selected by its independent selection,unlike previous studies which considered it as the results of the impaired metabolic pathways in cancer cells.Nowadays,the research hotspot of cancer has focused on the individualized treatment for the targets of energy metabolism disorder in cancer cells.This article reviewed the characteristics of cancer cell energy metabolism reprogramming,and explored the therapeutic mechanism for cancer treatment via traditional Chinese medicine(TCM)in terms of energy metabolism.