摘要
髓母细胞瘤(MDB)是儿童最常见的原发性恶性脑肿瘤,发生率仅次于儿童星形细胞瘤,约占儿童后颅窝肿瘤的40%。肿瘤转移(脑脊液种植)、肿瘤次全切除、大细胞/间变型MDB是具有统计学意义的不良预后因素。WNT型、标准危险组、M0期、术后放射治疗联合化学治疗、诊断年龄较大(≥3岁)、肿瘤全切除是预后的有利因素。本文围绕儿童MDB的流行病学特点和影响MDB预后的主要因素展开综述。
Medulloblastoma(MDB)is the most common primary malignant brain tumor in children,which is second only to pediatric astrocytoma and accounts for about 40%of posterior fossa tumors in children.We found that tumor metastasis(cerebrospinal fluid implantation),subtotal tumor resection and large cell/anaplastic MDB were statistically significant adverse prognostic factors.WNT subtype,standard risk group,M0 stage,postoperative radiotherapy combined with chemotherapy,older age(≥3 years old)at diagnosis and total tumor resection were favorable factors for prognosis.This review focuses on the epidemiological characteristics of pediatric MDB and the primary prognostic factors of MDB.
作者
陈立华
孙恺
陈文锦
夏勇
张洪钿
徐如祥
Chen Lihua;Sun Kai;Chen Wenjin;Xia Yong;Zhang Hongtian;Xu Ruxiang(Department of Neurosurgery,Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital,Chengdu 610072,China)
出处
《中华脑科疾病与康复杂志（电子版）》
2020年第4期239-243,共5页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
关键词
髓母细胞瘤
儿童
流行病学
预后
Medulloblastoma
Children
Epidemiology
Prognosis
