药物微生物组在新药研发中的应用

Application of pharmacomicrobiomics in new drug development

药物基因组学研究宿主基因层面对药物安全性与有效性的作用,指导新药研发过程。但宿主基因层面不能完全解释个体间药效差异。药物微生物组学是药物基因组学的重要扩展,研究肠道微生物对药物安全性与有效性的影响。目前与肠道微生物相关的大数据、多组学分析、粪菌移植、合成生物学等学科与技术已逐步在新药研发中应用,本文综述了新药研发的现状以及肠道微生物与药物相互作用,概括了目前肠道微生物相关药物的研发进展。

Pharmacogenomics promotes the success rate and efficiency of new drug development by targeting host genes.However,host gene level cannot fully explain the difference of drug efficacy among individuals.Pharmacomicrobiomics is an important extension of pharmacogenomics,which studies the effects of gut microbiome on drug safety and efficacy.At present,big data,Multinomial analysis,fecal bacteria transplantation,synthetic biology and other disciplines and technologies related to gut microbiome have been gradually applied in new drug development.This review introduces the current situation of new drug development and the interaction between gut microbiome and drugs,and summarizes the current research and development progress of gut microbiome related drugs.