肠道菌群与肠道屏障互作在炎症性肠病中的作用研究进展

Advance in study on interaction between gut microbiota and intestinal barrier in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种慢性非特异性肠道炎症性疾病,其发病机制复杂。IBD患者肠道菌群的组成与结构发生明显变化即肠道菌群失调。肠道屏障功能对维持人体肠道功能稳态发挥着重要调节作用。研究表明,在IBD中存在肠道屏障功能受损、肠道通透性增加。肠道菌群失调导致肠道屏障功能受损,从而破坏人体正常的肠道稳态功能,加重IBD的进展。本文将对肠道菌群与肠道屏障功能之间的互作在IBD发生发展及治疗中的应用进行阐述。这将为IBD的防治提供理论基础和新思路。

Inflammatory bowel disease(IBD)is a chronic nonspecific intestinal inflammatory disease with complex pathogenesis.The composition and structure of gut microbiota in patients with IBD are significantly changed,that is,dysbacteriosis.Intestinal barrier function plays an important regulatory role in maintaining intestinal homeostasis.Studies have shown impaired intestinal barrier function and increased intestinal permeability in IBD.The imbalance of gut microbiota leads to impaired intestinal barrier function,which destroys the normal intestinal homeostasis and aggravates the progression of the disease.The interaction between gut microbiota and intestinal barrier function and its application in the development and treatment of IBD will be described in this paper.This will provide theoretical basis and new ideas for the prevention and treatment of IBD.