血清前清蛋白水平检测对痛风疾病活动的诊断分析

Diagnostic analysis of the detection of serum prealbumin level in disease activity of gout

目的探讨血清前清蛋白(PA)水平检测对痛风疾病活动的诊断价值。方法回顾性分析2017年1月~2019年12月就诊于赣南医学院第三附属医院88例痛风患者的临床资料,根据临床症状不同分为间歇期组(30例)和急性发作期组(58例),并选同期健康体检者30例为对照组。比较三组患者的PA水平、血尿酸(UA)水平、红细胞沉降率(ESR)及超敏C反应蛋白(hs-CRP)水平,并分析痛风患者PA水平与UA、ESR、hs-CRP相关性。结果急性发作期组、间歇期组的PA水平低于对照组,UA、ESR、hs-CRP水平高于对照组,差异有统计学意义(P<0.05);急性发作期组的PA水平低于间歇期组,ESR、hs-CRP水平高于间歇期组,差异有统计学意义(P<0.05),而急性发作期组与间歇期组的UA水平比较,差异无统计学意义(P>0.05)。痛风患者的PA水平与ESR、hs-CRP水平呈负相关(r=-0.351、-0.472,P=0.001、0.000);PA水平与UA水平无明显相关性(P>0.05)。结论不同时期的痛风患者PA、UA、ESR、hs-CRP存在明显差异,且PA水平与ESR、hs-CRP水平呈负相关,可将PA水平作为痛风疾病活动判断的辅助指标。

Objective To explore the diagnostic value of the detection of serum prealbumin(PA)level in the disease activity of gout.Methods The clinical data of 88 patients with gout who treated in the hospital from January 2017 to December 2019 were retrospectively analyzed.They were divided into intermission group(30 cases)and acute attack group(58 cases)according to different clinical symptoms,and 30 healthy people with physical examination during the same period were selected as control group.The levels of PA level,blood uric acid(UA),erythrocyte sedimentation rate(ESR)level and high-sensitivity C-reactive protein(hs-CRP)level were compared among the three groups,the correlation of PA level with UA,ESR and HS-CRP in patients with gout was analyzed.Results The level of PA in the acute attack group and the intermission group were lower than that in the control group,and the levels of UA,ESR and hs-CRP were higher than those in the control group,the differences were statistically significant(P<0.05).The level of PA in the acute attack group was lower than that in the intermission group,the levels of ESR,hs-CRP were higher than those in the intermission group,the differences were statistically significant(P<0.05).There was no statistical difference in the level of UA between the acute attack group and the intermission group(P>0.05).The PA level of patients with gout was negatively correlated with ESR and hs-CRP level(r=-0.351,-0.472,P=0.001,0.000),There was no significant correlation between PA level and UA level(P>0.05).Conclusion PA,UA,ESR,and hs-CRP of gout patients in different periods are significantly different,and PA levels are negatively correlated with ESR and hs-CRP levels.PA levels can be used as auxiliary indicators for judging gout disease activity.