Dickkopf家族蛋白在非小细胞肺癌中的作用机制和治疗应用的研究进展

Research progress on the mechanism and treatment of Dickkopf family protein in non-small cell lung cancer

非小细胞肺癌(Non-small cell lung cancer,NSCLC)占所有肺癌的80%~85%,是全世界发病率和致死率极高的恶性肿瘤。最初NSCLC对现有治疗的反应良好,但最终还是产生了耐药性。因此,有必要探索有效且新颖的治疗方法。随着对NSCLC研究的深入,发现Dickkopf家族蛋白(DKKs)的信号传导在NSCLC发展中扮演重要角色,DKKs是Wnt/β-catenin信号通路的重要调节因子,并与NSCLC细胞增殖、转移和侵袭密切相关。本文主要介绍了DKKs家族成员在NSCLC中的作用机制,讨论了DKKs在NSCLC治疗中的潜力,为进一步防治NSCLC提供了新思路。

Non-small cell lung cancer(NSCLC)accounts for 80%to 85%of all lung cancers,and it is a malignant tumor with extremely high morbidity and mortality over the world.Initially,NSCLC has responded well to existing treatments,but it eventually has developed resistance.Therefore,it is necessary to explore effective and novel treatment methods.With the in-depth study of NSCLC,it is found that Dickkopf family protein(DKKs)signaling plays an important role in the development of NSCLC.DKKs are important regulators of the Wnt/β-catenin signaling pathway and are closely related to proliferation,metastasis and invasion of NSCLC cells.This article mainly introduces the mechanism of DKKs family members in NSCLC,discusses the potential of DKKs in the treatment of NSCLC,and provides new ideas for the further prevention and treatment of NSCLC.