靶向抑制FGFRs信号在治疗恶性肿瘤中的研究进展

Research progress of targeted inhibition of FGFRs signal in the treatment of malignant tumors

成纤维细胞生长因子受体(Fibroblast growth factor receptors,FGFRs)通过与配体-成纤维细胞生长因子(FGFs)结合调节细胞的生长、增殖和血管生成等。越来越多的研究表明FGFRs信号是恶性肿瘤的驱动因素,在肿瘤血管生成和癌细胞分裂增殖的过程中起重要作用。本文就FGFRs信号通路在生理、病理以及恶性肿瘤中的作用机制做一综述,为临床上开发靶向抑制FGFRs信号、完善肿瘤治疗方案提供依据。

Fibroblast growth factor receptors(FGFRs)regulates cell growth,proliferation and angiogenesis by binding with ligand fibroblast growth factors(FGFs).More and more studies have shown that FGFRs are the driving factor of some malignant tumors,and play an important role in the process of tumor angiogenesis and tumor cell division and proliferation.This article reviews the mechanism of FGFRs signaling pathway in physiology,pathology and malignant tumor,and provides a basis for clinical development for targeted inhibition of FGFRs signaling and the improvement of tumor treatment programs.