lncRNA-HEIH在肿瘤中的研究进展

Research progress of lncRNA-HEIH in tumor

长链非编码RNA(Long non-coding RNA,lncRNA)是一类新的非编码RNA,参与多种疾病的生物学进程。lncRNA-HEIH(High expression in hepatocellular carcinoma,HEIH)通过不同机制调节肿瘤增殖、迁移、侵袭、凋亡以及耐药,其表达水平与肿瘤的临床病理特征相关,在肿瘤发生发展中起关键作用。本文简要介绍了lncRNA-HEIH的概念,对其在肝细胞肝癌、肺癌、乳腺癌、结直肠癌、子宫内膜癌等多种恶性肿瘤中的生物学功能和分子机制进行了系统的综述,探讨了lncRNA-HEIH成为潜在的生物标记物和新的肿瘤治疗靶点的前景。

Long non-coding RNAs(lncRNA)are a new class of non-coding RNAs that participate in the biological processes of many diseases.lncRNA-HEIH(High expression in hepatocellular carcinoma,HEIH)regulates tumor proliferation,migration,invasion,apoptosis and drug resistance through different mechanisms.Its expression level is related to the clinicopathological characteristics of tumors and plays a key role in tumor occurrence and development.This article briefly introduces the concept of lncRNA-HEIH,and systematically reviews its biological functions and molecular mechanisms in hepatocellular carcinoma,lung cancer,breast cancer,colorectal cancer,endometrial cancer and other malignant tumors.The prospect of lncRNA-HEIH is considered as a potential biomarker and a new target for cancer treatment.