基于负压吸引式冷冻溶脂降温效果的仿真及实验

Simulation and experiment on cooling effect of cryolipolysis based on negative pressure suction

目的:评估冷冻溶脂治疗过程的降温效果,为临床治疗提供理论依据。方法:依据负压吸引式冷冻溶脂装备结构建立物理模型,通过数值模拟的方法评估不同溶脂温度以及血液灌注率对降温效果的影响,并进行实验验证了模型的准确性。结果:模拟结果表明,不同制冷温度下,低于溶脂温度的脂肪厚度占比为10.11%~40.32%,与临床的减脂效果10.7%~37.5%相比,模拟结果与临床结果较为一致。较小的脂肪血液灌注率会提升降温效果,但当脂肪血液灌注率小于1.44×10^-4s^-1时,冷冻溶脂降温效果的提升较小。实验结果表明,模拟值与实验值降温趋势一致,在最终时刻温度相差1~2℃,证实数值模拟结果的准确性。结论:研究结果可以为临床评估及优化冷冻溶脂效果提供可靠的理论依据。

Objective To evaluate the cooling effect of cryolipolysis therapy and provide theoretical basis for clinical treatment.Methods A physical model was established based on the structure of negative pressure suction cryolipolysis equipment and evaluated the effects of different cryolipolysis temperatures and blood perfusion rate on the cooling effect by numerical simulation.The accuracy of the model was verified.Results The simulation results showed that the proportion of fat thickness below the cryolipolysis temperature is 10.11%-40.32%under different refrigerating temperature.Compared with the clinical fat reduction effect of 10.7%-37.5%,the simulation results are consistent with clinical results.A smaller fat blood perfusion rate can improve the cooling effect.However,when the fat blood perfusion rate is less than 1.44×10^-4 s^-1,the cooling effect of cryolipolysis is slightly improved.The test results also showed that the simulation and the test have the same cooling trend,and the temperature difference at the final moment is 1℃-2℃,which confirms the accuracy of the numerical simulation results.Conclusion The research results may provide a reliable theoretical basis for clinical evaluation and effect optimization of cryolipolysis.