不同年龄宫颈癌患者Ki67表达及病理特征比较

Comparative Study on Ki67 and Pathological Characteristics of Cervical Cancer Patients of Different ages

目的比较不同年龄阶层宫颈癌患者Ki-67的表达、临床病理特征差异,并分析其相关性。方法回顾整理经手术并治疗的宫颈癌患者81例;根据患者年龄分为青年组(≤35岁,n=22)、中年组(36~49岁,n=31)、老年组(≥50岁,n=28);整理各组患者临床资料,比较分析各组患者Ki-67表达水平、肿瘤分类、临床分期、预后等情况。结果青年组患者的临床症状与中年组和老年组具有显著差异,其中不规则阴道出血占比明显低于中年组和老年组(P<0.05),接触性出血、白带异常占比均明显高于中年组和老年组(P<0.05)。而中年组、老年组在出血、白带异常方面差异无统计学意义(P>0.05)。三组患者宫颈癌组织Ki67表达情况:Ki67阳性青年组9例,中年组17例,老年组15例,三组间差异无统计学意义(P>0.05)。在肿瘤大小、FIGO分期、淋巴结转移方面青年组、中年组、老年组间差异无统计学意义(P>0.05),但青年组宫颈深肌层受累情况明显优于中年组和老年组(P<0.05)。81例宫颈癌患者Ki67表达与肿瘤大小、FIGO分期无显著相关性(P<0.05),与淋巴结转移和宫颈深肌层受累呈显著相关(P<0.05)。结论不同年龄阶层宫颈癌患者的临床表现与病理特征方面均存在一定差异,加强对临床表现及病理特征观察,有利于患者临床诊断,为疾病治疗创造有利条件。

Objective To compare the expression of Ki-67,clinicopathological characteristics of cervical cancer patients with different ages and analyze their correlation.Methods 81 cases of cervical cancer diagnosed by operation and treatment were divided into youth group(≤35 years old,n=22),middle-aged group(36~49 years old,n=31),and elderly group(≥50 years old,n=28)according to the age of the patients;collated the clinical data of each group,compared and analyzed the expression,tumor classification,clinical stage,prognosis and so on.Results The clinical symptoms of the patients in the youth group were significantly different from those in the middle-aged group and the elderly group,in which the proportion of irregular vaginal bleeding was significantly lower than that in the middle-aged group and the elderly group(P<0.05).but the middle-aged group and the elderly group had no significant difference in bleeding and leucorrhea abnormalities(P>0.05).The analysis of cervical cancer tissue Ki67 expression in the three groups showed that there were 9 positive Ki67 in the youth group,17 in the middle age group and 15 in the elderly group,and there was no significant difference between the three groups(P>0.05).There was no significant difference in tumor size,FIGO stage,lymph node metastasis between the youth group,middle-aged group and the elderly group(P>0.05),but the involvement of deep cervical muscle layer in the youth group was significantly better than that in the middle-aged group and the elderly group(P<0.05).There was no significant correlation between Ki67 expression and tumor size and FIGO stage in 81 patients with cervical cancer(P<0.05),and significant correlation with lymph node metastasis and deep cervical myometrium involvement(P<0.05).Conclusion There are some differences in the clinical and pathological features of cervical cancer patients of different age groups,and strengthening the observation of clinical manifestations and pathological features is beneficial to the clinical diagnosis of patients and to create favorable conditions for the treatment of diseases.