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关爱强直,救助贫困:“强直性脊柱炎健康扶贫工程”项目介绍 被引量:2

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摘要 强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎症性疾病,主要影响脊柱、骶髂关节及外周关节,中轴关节持续性炎症导致炎性背痛是其主要症状,受累关节可发生进行性融合,导致脊柱活动受限和畸形,造成患者残疾,严重影响生活质量和社会工作能力[1-2]。在亚洲,AS平均患病率为16.7/10000[3],在我国的患病率约为0.3%,有近500万例患者。AS通常在30~40岁发病,男性易患,约占80%~85%。
出处 《中华临床免疫和变态反应杂志》 2020年第6期521-523,共3页 Chinese Journal of Allergy & Clinical Immunology
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  • 1Zink A, Braun J, Listing J, et al. Disability and handicap in rheumatoid arthritis and ankylosing spondylitis: results from the German rheumatological database. J Rheumatol, 2000, 27: 613- 622.
  • 2Shealy DJ, Wooley PH, Emmell E, et al. Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice. Arthritis Res, 2002, 4(5): R7.
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  • 6Mander M, Simpson JM, McLellan A, et al. Studies with an enthesis index as a method of clinical assessment in ankylosing spondylitis. Ann Rheum Dis, 1987, 46: 197-202.
  • 7Jenkinson TR, Mallorie PA, Whitelock HC, et al. Defining spinal mobility in ankylosing spondylitis (AS): the Bath AS metrology index. J Rheumatol, 1994, 21: 1694-1698.
  • 8Anderson J J, Baron G, Van der Heijde D, et al. Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum, 2001, 44: 1876-1886.
  • 9Bran& J, Khariouzov A, Listing J, et al. Six-month results of a double blind, placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis. Arthritis Rheum,2003, 48: 1667-1675.
  • 10Davis JC, Van Der Heijide D, Braun J, et al. Recominant human tumor necrosis factor receptor (etanercept) for treating ankylosing: a randomized, controlled trial. Arthritis Rheum, 2003, 48: 3230-3236.

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