慢性肾脏病与肠道菌群相关性研究进展概述

Summary of research advances on the correlation between chronic kidney disease and gastrointestinal microbiome

中国慢性肾脏病(chronic kidney disease,CKD)发病率高,呈逐年增长趋势,目前尚无根治手段,积极探索CKD进展的危险因素是目前肾脏病领域的研究重点。近年越来越多学者指出,肠道菌群变化与CKD发生发展存在一定相关性,肠道微生态平衡对人体健康有着举足轻重的作用,而CKD患者肠道黏膜受损后可引起肠道菌群紊乱,继发肠源性毒素堆积,加重CKD进展;本文就目前国内外有关CKD与肠道菌群研究进行概述,进一步探讨以调节肠道菌群紊乱作为CKD防治新靶点的可能性。

The incidence of chronic kidney disease(CKD)in China has remained elevated and it shows an annually rising trend.However,no radical cure is not currently available.Exploring the risk factors of CKD is a research focus of nephrology.It is generally accepted that the change of intestinal flora was correlated with the development of CKD.And micro-ecological balance of gut might impact upon human health.However,owing to an impairment of intestinal function barrier and an alteration of intestinal flora,an accumulation of gut derived toxin gradually induced a continuous deterioration of CKD.This review was intended to describe the relativity between CKD and intestinal flora and explore the possibility of modulating intestinal flora as a new therapeutic target for CKD.