pH响应性电荷反转型共聚物纳米粒的构建及其光热性能考察

Construction and Photothermal Property of pH-responsive Charge-reversal Copolymer Nanoparticles

利用多巴胺和5-羟色胺在碱性条件下能发生氧化自聚合反应的特性,制备了pH响应性电荷反转型共聚物纳米粒(PDH NPs)。采用透射电镜、紫外吸收光谱及红外光谱对所得纳米粒进行表征,并考察了纳米粒的pH响应性电荷反转能力及光热性能。结果表明,制备的PDH NPs呈均一的球形结构,粒径约100 nm。在体外,PDH NPs在pH 7.6条件下带负电,在pH 6.0下带正电,表现出pH响应性的电荷反转能力。PDH NPs同时具有明显的光热效应,且该光热效应具有可重复性。本研究为构建具有肿瘤靶向性及光热治疗协同抗肿瘤作用的多功能纳米载体提供了新思路。

According to the oxidative self-polymerization of dopamine and 5-hydroxytryptamine under alkaline conditions,the pH-responsive charge-reversal copolymer nanoparticles(PDH NPs)were prepared in this paper.The nanoparticles were characterized by transmission electron microscopy(TEM),ultraviolet absorption spectroscopy(UV)and infrared spectroscopy(IR).The charge-reversal ability and photothermal property of the prepared nanoparticles were also investigated.The results showed that PDH NPs had uniform spherical shapes with particle size of about 100 nm.The copolymer nanoparticles were negatively charged in pH 7.6 medium and positively charged in pH 6.0 medium,showing the pH-responsive charge-reversal ability in vitro.Meanwhile,the PDH NPs had obvious photothermal effect with repeatability.This study would provide a new idea for the construction of multifunctional nanoparticles with synergistic effects of tumor targeting and photothermal therapy.