Hedgehog信号通路对骨髓间充质干细胞的调控作用

Regulations of Hedgehog signaling pathway on bone mesenchymal stem cells

骨髓间充质干细胞具有分化为成骨细胞、软骨细胞和脂肪细胞等多种细胞的潜能,对骨发育和骨的稳态维持至关重要。Hedgehog分泌信号在多种组织器官形成和疾病过程中具有重要调控作用。本文通过查阅国内外文献,主要综述Hedgehog信号通路对骨髓间充质干细胞三向分化的调控作用,在骨相关疾病中Hedgehog信号通路的研究进展,以及通过不同干预手段介导Hedgehog信号通路对骨髓间充质干细胞的影响,为进一步的研究提供思路。

Bone mesenchymal stem cells can differentiate into osteoblasts,chondrocytes,adipocytes and other cells,playing a vital role in bone development and maintenance of bone homeostasis.Hedgehog signaling is involved in the different process of organ formation and diseasese progress.This paper mainly summarized the regulation effect of Hedgehog signaling pathway on bone mesenchymal stem cell differentiation and the research progress of Hedgehog signaling pathway in bone-related diseases,as well as intervention methods targeting Hedgehog signaling pathway,providing ideas for further research.