5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶-2-甲酸盐酸盐的合成

Synthesis of 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-formic Acid Hydrochloride

以N-甲基-4-哌啶酮为起始原料,通过与氰胺、单质硫发生成环反应,合成5-甲基-4,5,6,7-四氢苯并[5,4-c]吡啶-2-胺,再经过取代反应、成盐反应得到2-溴-5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶对甲苯磺酸盐,最后通过游离、成盐合成5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶-2-甲酸盐酸盐。

Using N-methyl-4-piperidone as starting material,5-methyl-4,5,6,7-tetrahydrobenzo[5,4-c]pyridin-2-amine was synthesized by cyclization reaction with cyanamide and elemental sulfur.After substitution reaction and salt formation reaction,2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate was obtained.Finally,5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-formic acid hydrochloride was synthesized through free and salt formation.