氟氧头孢钠的合成

Synthesis of Flomoxef Sodium

以7β-二氟甲基硫代乙酰氨基-3-氧头孢母核为原料,经缩合反应,再用四氯化钛脱羧基保护,最终用异辛酸钠成盐,通过结晶法得到氟氧头孢钠,总收率约82.9%。

Flomoxef sodium was synthesized from 7β-difluoromethylsulfanyl-acetylamino-3-oxycephalin mother nucleus by condensation,decarboxylation protection with titanium tetrachloride,finally saltification from sodium iso-octoate and crystallization.The overall yield is about 82.9%.