乳酸菌调控胆固醇代谢关键因子的研究进展

Research Progress of Regulatory Key Factors Involved in Cholesterol Metabolism by Lactic Acid Bacteria

人体内胆固醇代谢失衡会引发多种疾病,严重威胁人类健康。如何调控机体内、外胆固醇的代谢,是当今至关重要的课题之一。乳酸菌作为人体肠道内的正常菌群,在调节人体内的代谢等方面发挥着十分重要的作用。乳酸菌可以通过调控胆固醇代谢过程中关键因子的表达,对机体内、外胆固醇水平起到调节作用,如:调节胆固醇合成代谢中的3-羟基-3-甲基戊二酰辅酶A还原酶(HMGCR);调控胆固醇分解代谢中的胆固醇7α-水解酶(CYP7A1);调节胆固醇吸收及转运过程中的ATP结合盒转运蛋白家族成员ABCG5/G8及多蛋白跨膜蛋白NPC1L1蛋白等。本文概述了乳酸菌调控胆固醇代谢过程中关键因子的相关研究,旨在为深入研究乳酸菌调控机体胆固醇代谢机制提供理论基础。

The metabolism disorders of cholesterol would trigger several diseases,which could threaten human health seriously.How to regulate and control the metabolism of cholesterol in vitro and vivo is supposed to be one of the most important issue nowadays.The Lactobacillus is the normal flora existing in human intestine,acting as an important role on adjusting the metabolism.The Lactobacillus can influence the level of cholesterol through regulating the expression of key factors in the process of cholesterol metabolism.Those factors include,the HMG-CoA in the synthesizing process of cholesterol metabolism,the CYP7A1 in the catabolism process of cholesterol metabolism,the ABCG5/G8 and NPC1L1 in the absorption and transportation process of cholesterol metabolism,etc.This paper states the related research in terms of key factors that act on the process of the Lactobacillus regulate and control the metabolism of cholesterol.The aim of the paper is to provide theoretical basis of further study on Lactobacillus regulate cholesterol metabolism.