外泌体在血液肿瘤微环境中的作用及其诊治意义

Role of Exosome in Microenvironment of Hematological Malignancies and Its Diagnostic and Therapeutic Potential

外泌体是细胞外囊泡的一类主要成分,是正常生理情况下组织细胞间信号传递的重要介质;在多种血液肿瘤研究中发现外泌体是骨髓微环境各成分间相互作用的关键载体,由于其广泛存在并含有特定的核酸、蛋白等分子,外泌体被作为潜在的生物标志物和治疗靶点/载体,在血液肿瘤诊治中的重要性近年正逐步受到关注。

Exosome,a major component of extracellular vesicles,is an important media for intercellular communications under physiological conditions.In a variety of hematological malignancies researches,it has been demonstrated that exosome acts as the key carrier for interactions among the components of the bone marrow microenvironment.Due to its widespread existence and containing specific nucleic acid and protein molecules,the importance of exosome as a potential biomarker and therapeutic target/carrier in the diagnosis and treatment of hematological malignancies has been attracting more attention in the past few years.