内质网应激对缺血性脑卒中神经元凋亡与自噬的调控及中医药的干预

The Regulation of Traditional Chinese Medicine on Neuronal Apoptosis and Autophagy via Endoplasmic Reticulum Stress after Ischemic Stroke

内质网作为细胞内的一种膜质细胞器,通过参与分泌蛋白和跨膜蛋白的合成、折叠、成熟和翻译后修饰以维持细胞内稳态,与疾病的发生发展密切相关。当内质网环境受到干扰后蛋白质将发生折叠或错误折叠,此时内质网应激被激活,可对神经元的凋亡与自噬进行调控,在缺血性脑卒中中扮演着重要角色。本文从内质网应激的信号通路入手,探讨内质网应激与神经元凋亡和自噬的关系,介绍中医药通过内质网应激途径调控缺血性脑卒中神经元凋亡与自噬的研究概况,为研究中医药在缺血性脑卒中的作用机制提供新的现代医学的理论支持和作用靶点。

The endoplasmreticulum,being as an intracellular mesangial organelle,maintains homeostasis by participating in the synthesis,folding,maturation,and post-translational modification of secreted and transmembrane proteins,which is closely related to the development of disease.When the endoplasmic reticulum environment is disturbed,folding or misfolding of protein starts,and followed with the activation of the endoplasmic reticulum stress.The latter can regulate the neuron s apoptosis and autophagy.This article aims to explore the relationship between neuronal apoptosis and autophagy via endoplasmic reticulum stress signal pathways,also the mechanisms of traditional Chinese medicine(TCM)at this area are presented,which would provide new theoretical support and target of modern medicine for the mechanism of TCM in ischemic stroke.