线粒体DNA在创伤中的作用机制

Mechanism of action of mitochondrial DNA in trauma

创伤是导致器官和组织损伤最直接的形式,也是世界范围内致死和致残的主要原因之一。创伤伴随的缺血再灌注、酸中毒、低氧血症、外科手术、失血或大量输血等均可引起继发性组织损伤。创伤导致内源性损伤相关分子模式(DAMPs)大量释放,引发全身炎症反应综合征(SIRS),进而导致脓毒症、多器官功能衰竭甚至死亡。近期研究表明,线粒体DNA(mtDNA)等线粒体来源的DAMPs在炎症反应中发挥重要作用。mtDNA的释放不仅能够诱导免疫应答、加剧炎症反应,甚至导致组织及器官损伤。本文就mtDNA在创伤中的释放机制,发挥作用的信号通路,及其与创伤的治疗策略和预后进行综述。

Trauma is the most direct form of organ and tissue damage and one of the leading causes of death and disability in the world.Secondary tissue damage can be caused by ischemia-reperfusion,acidosis,hypoxemia,surgery,hemorrhage and massive blood transfusion associated with trauma.Trauma releases a large number of endogenous damage-associated molecular patterns(DAMPs),triggers systemic inflammatory response syndrome(SIRS),sepsis,multiple organ failure,and even death.Recent studies have shown that mitochondrial-derived DAMPs such as mitochondrial DNA(mtDNA)play an important role in the inflammatory response.The release of mtDNA induces an immune response,exacerbates the inflammatory responseand causes damage to tissues and organs.This review focuses on the release mechanism and the signaling pathways of mtDNA,the relationship between mtDNA and the prognosis of trauma and therapeutic strategies for release of mtDNA intrauma.